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BCP Cannabinoid beta Caryophyllene, THC and CBD are the most widely researched cannabinoids in Cannabinoid science. However, the reality is that these compounds are only part of the story.
beta Caryophyllene (BCP), along with at least other 113 other Cannabinoids, operate in sync with hundreds of other compounds to modulate BCP’s therapeutic effects when consumed and ultimately give BCP its versatility, potentially providing relief for a multitude of ailments.
“The whole is greater than the sum of its parts.”- Aristotle
The term “entourage effect” refers to the concept that all the unique components of a plant work together in concert to exert a therapeutic effect greater than any single compound by itself.
A 1981 research study by scientists J.W. Fairbairn and Joan T. Pickens provided evidence confirming the existence of the entourage effect in Cannabinoids. Using the ring test, the researchers demonstrated that whole plant extracts produced 330% more activity than the isolated plant compound alone. They hypothesized that plant Cannabinoids contain “synergist” and “inhibitor” compounds – serving to enhance therapeutic effects while inhibiting potentially negative reactions.
How is this possible? Cannabinoid containing plants are complex, with hundreds of molecules and compounds, including cannabinoids, terpenes, flavonoids and other phytochemicals, each of which is thought to affect the brain and body in a different way.
These elements interact synergistically to produce and amplify the overall therapeutic benefits of Cannabinoids. The term “entourage effect” refers to this phenomenon with results that may make the whole plant more beneficial than the sum of its individual molecules.
THE ENTOURAGE EFFECT: Whole Plant Liquid Extracts versus Isolates.
This notion that the compounds present in plant cannabinoids work in concert to produce stronger benefits than they would separately was first introduced in a 1998 Paper: An entourage effect: inactive endogenous fatty acid glycerol esters enhance cannabinoid activity by scientists Shimon Ben-Shabat and Raphael Mechoulam. The scientists were the first to establish that it is the synergistic relationship between these compounds that is largely responsible for the therapeutic effects of Cannabinoids.
Expanding on this in a 2009 paper“Synergy research: Approaching a new generation of phytopharmaceuticals,” scientists Hildebert Wagner and Gudrun Ulrich-Merzenich outlined and discussed the following basic mechanisms of the entourage effect:
- Whole-plant derived compounds can affect multiple targets within the body.
- Whole plant synergy improves the bioavailability, absorption and solubility rate of active compounds.
- Whole plant synergy assists in overcoming bacterial defense mechanisms.
- Whole plant synergy contributes to minimizing adverse side effects of active compounds.
From this research, it’s clear that the entourage effect supports the idea that whole plant medicine is superior to single isolated molecules.
THE TERPENE ASSIST
“…synergism may play a role in the widely held (but not experimentally based) view that in some cases plants are better drugs than the natural products isolated from them.” – Ethan Russo, M.D.
Ethan Russo, M.D., a neurologist who now serves as director of research and development at the International Cannabinoids Institute, published an article in the British Journal of Pharmacology in 2011 Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects in which he details how plant compounds influence each other’s mechanisms. The article, was one of the first to examine how the entourage effect works when Cannabinoids are administered to mammals.
Russo found that terpenes – the fragrant plant oils that give plants their smell – are quite potent on their own, and provide a broad range of effects, including sedative, anti-bacterial, anti-inflammatory and palliative therapy. However, he also uncovered how terpenes seem to change the way in which Cannabinoids bind to their respective receptors, thus altering the way in which Cannabinoids take effect internally.
Stating that cannabinoid-terpenoid interactions “could produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections,” Russo suggested that further research into the entourage effect holds great potential for improved pharmaceutical solutions through plant phytochemistry.
WHAT DOES THIS MEAN FOR CANNABINOID-BASED THERAPIES?
The entourage effect implies that we’re not just relying on one thing – not just (BCP) Cannabinoid beta Caryophyllene for example, but rather, a combination of compounds. Because you are using Our BCP+ Cannabinoid product that has more than one active ingredient, i.e, it is a Whole Plant Extract containing the phyto-Cannabinoid BCP & Terpenes, you are getting benefit from the entourage effect. Your result is greater than if you just used one of those compounds.”
Reflecting on this effect in conjunction with the current lack of an established standard of care in Cannabinoid dosing, it could be viewed as a positive opportunity for ownership of self-care.
It empowers the User, it gives the User ownership over their own care, self determining what they put into their body, & how they do so. They can choose their product and select their preferred method of delivery – sublingual is an option, as is an edible, vaping another, and so on. They are able to medicate with as much or as little as they need because it is a very safe holistic therapy – much safer than opioids.
Acknowledging that there is not currently a way to properly recommend exact dosage for every individual, Users must monitor their own responses to product, dosage and delivery method that caused the effect.
When embarking on Self Care Cannabinoid therapy, start with what you are comfortable with in terms of (BCP) Cannabinoid beta Caryophyllene content, and dosing method.
Typically with (BCP) Cannabinoid beta Caryophyllene products, individual effects need to be taken into account. When dosing BCP, Users need to make themselves aware of what’s available, what to expect when they start their Cannabinoid self therapy, and to adjust accordingly to their bodily responses & needs.
The entourage effect suggests that unlike pharmaceutical drugs that work best as single compounds, using Our Whole Plant extract, BCP+ Cannabinoid, likely offers the most benefit. Despite these promising studies, the entourage effect is still hotly debated in scientific circles and there is a growing effort to prove its validity. This increased interest reflects changing attitudes the World over, about Cannabinoid use for medicinal self therapy.
The American FDA approval of GW Pharmaceuticals’ Epidiolex for seizure management of patients with Lennox-Gastaut syndrome and Dravet syndrome for example, is another indication of the growing acceptance of cannabinouid-based therapies.
There is much left to be uncovered in the potential of plants that impact the Endocannabinoid System. Studying the entourage effect will be key to furthering our understanding of how the components of Plant Cannabinoids, all work in concert together. This could lead to the development of innovative plant based therapies tailored directly to specific User needs, and has the potential to revolutionize the medicinal Cannabinoid Industry.
β-caryophyllene (BCP). The Phyto Cannabinoid Super Molecule!
*Decoding Key words: cerebral ischemia, Ulcerative Colitis, Dyslipidemia, Glioblastoma, Liver fibrosis, Immunomodulatory, Atherosclerosis, Mucositis Nephrotoxicity, Cardiotoxicity, Alzheimers Disease, Parkinsons Disease. Multiple Sclerosis. Neuropathic Pain, Neurodegenerative disease, Amyotrophic lateral sclerosis (ALS) aka Motor Neurone Disease (MND), *in vitro versus in vivo Studies?
BCP+ 30x Liquid Extract Cannabinoid Oil beta Caryophyllene is a powerful, non psychoactive, all natural, plant based herbal Liquid extract & Balm, that targets the C.B 2 Cannabinoid Receptors, & may provide a legal alternative to ‘Prescription Only’ Cannabidiol (C.B.D) preparations, such as Tilray, Elixinol, & Sativex.
There are many commercially available Cannabis preparations rich in β-caryophyllene (BCP), including: Elixinol®, Sativex®, Tilray®, Bedrocan®, Marinol®, Bedrobinol®, Namisol®, Arvisol®, Fenoxidol™, Epidiolex® etc. Hebaallah Mamdouh Hashiesh et al, 2021
Our BCP+ Cannabinoid beta Caryophyllene herbal remedies are 100% natural, Whole Plant based extracts, rich in the phyto Cannabinoid beta Caryophyllene & Terpenes: Myrcene, Linalool, Pinene, Humulene, Trans-nerolidol, et al, contain NO Prohibited OR Restricted substances, & are NON PSYCHOACTIVE, targeting the CB2 Cannabinoid Receptors, therefore devoid of any psychoactive side effects.
Our source Plants, native to the Americas, have one of the highest beta Caryophyllene profiles in the Plant Kingdom, even greater than Cannabis -Hemp!
‘ BCP (beta Caryophyllene) binds to the endocannabinoid receptors, along with its better-known cannabinoid cousins, THC, CBD, and CBN. The main difference between BCP and its cannabinoid relatives is that it only attaches to the CB2 receptors and not the CB1 receptors. CB2 receptors are most often found in the cells of our immune system, hence leading to the amazing benefits of BCP.‘ Elixinol.com
Introductory Offer:
Ultra High Potency 5 ml, 20 ml, 100 ml, 500 ml, 1 Litre BCP+ 30x Liquid Extract Cannabinoid Oil beta Caryophyllene: E.V Olive Oil OR V.G – Vegetable Glycerine.
Ultra High Potency 5 ml Sampler BCP+ 30x Extract Cannabinoid Oil, dropper bottle, @ $25. *plus p & p. Extra Virgin Olive Oil OR V.G – Vegetable Glycerine.
Ultra High Potency 20 ml BCP+ 30x Extract Cannabinoid Oil, dropper bottle, @ $99. *plus p & p. E.V Olive Oil OR V.G – Vegetable Glycerine.
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NEW! Ultra High Potency 1 Litre BCP+ 30x Liquid Extract Cannabinoid Oil @ $ *Sold Out, Order on Request. *Includes FREE POST! Save $10.
*Sold Out, Order on Request. = 24 hour turnaround once payment clears.
E.V.O.O – Extra Virgin Olive Oil – E.V Olive Oil taste.
V.G – Vegetable Glycerine – tastes sweet like Liquid honey, with a hint of Liquorice.
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New Zealand Online Apothecary - BCP+ 30x Cannabinoid Oil beta Caryophyllene (BCP) Whole Plant Liquid Extracts & Balm. 