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Cannabinoids have been receiving more and more attention in the news lately and you may find yourself wondering: what is the endocannabinoid system and what role does it play in the human body?

The endocannabinoid system works to keep the human body in balance.

In order to understand the endocannabinoid system, it’s also important to understand the key biological concept of homeostasis, which refers to any process or reaction that the body utilizes to actively maintain a stable internal environment. In many cases, these functions geared towards maintaining balance are necessary for any organism to survive.

Disturbances to physiological equilibrium, if uncorrected, can lead to impaired health, with symptoms that range from headaches to more serious diseases like arthritis, epilepsy, stroke, obesity, Alzheimer’s disease, cancer, and glaucoma. The body’s ability to adjust to changes and maintain homeostasis directly impacts the state of health of that organism.

The endocannabinoid system is a molecular system responsible for regulating and balancing many processes in the body, including immune response, communication between cells, appetite and metabolism, memory, and more.

It is through this system of receptors and metabolic enzymes that cannabinoids interact with the human body and trigger beneficial effects.

Despite the integral role the endocannabinoid system has in human body function, it was discovered relatively recently and much of its importance is only just becoming understood by scientists and the medical community at large.

YouTube Link – Visualization of The Endocannabinoid Signaling System

A Brief History of the Endocannabinoid System

“Relax, eat, sleep, forget and protect.” ~ Vincenzo Di Marzo

In 1998, Vincenzo Di Marzo, one of the world’s leading cannabinoid scientists, stated that these physiological processes in the human body: mood, appetite, sleep, memory, and pain-sensation are in the domain of a biological regulatory system wired to keep the body in balance.

Named after the plant that led to its discovery, the endogenous cannabinoid system is perhaps the most important physiologic system involved in establishing and maintaining human health.

It is composed of endocannabinoids, which are endogenous lipid-based retrograde neurotransmitters that bind to cannabinoid receptors, and cannabinoid receptor proteins that are found throughout the body in the brain, organs, connective tissues, glands, and immune cells.

In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: homeostasis or equilibrium. In fact, almost every physiological process is affected by the endocannabinoid system on some level. This means it can be targeted to treat many diseases.

What is surprising is that the endocannabinoid system was discovered less than 30 years ago.

In 1964, Dr. Raphael Mechoulam, successfully isolated , a non-psychotropic cannabinoid generally associated with antioxidant and neuroprotectant properties.

These cannabinoids are referred to as “phytocannabinoids” because they are naturally occurring in plants. Being able to isolate these phytocannabinoids for the first time was a critical stepping stone in discovering the endocannabinoid system.

The Cannabis plant contains beta Caryophyllene (BCP), a non psychoactive phytocannabinoid that activates the CB 2 Receptors in humans.

In 1990, a molecular biologist, Lisa Matsuda and her colleagues at the National Institute of Mental Health identified the endocannabinoid system.

Shortly thereafter, Mechoulam’s research led him to the discovery of two endocannabinoids: anandamide and 2-arachidonoylglycerol, or 2-AG.

Endocannabinoids are cannabinoids that are naturally produced in the body by the brain.

These endocannabinoids bind to cannabinoid receptors on target cells throughout the body, triggering a cellular response which is amplified or diminished as metabolic enzymes destroy or make more endocannabinoids.

This activity produces diverse effects that range from anti-inflammatory responses to euphoria. 

“By using plants that have been around for thousands of years, we discovered a new physiological system of immense importance. We wouldn’t have been able to get there if we had not looked at these plants.” ~ Mechoulam

These discoveries triggered an explosion of research exploring the endocannabinoid system. The system has been implicated in multiple physiological functions and we now have valuable knowledge about the pharmacology, biochemistry, and clinical effects of endocannabinoids.

It has been established that endocannabinoids have a role in the pathology of many disorders and it is believed that they also serve a “protective role” in many medical conditions.

Diseases like pain, inflammation, multiple sclerosis, anorexia, epilepsy, glaucoma, anxiety, depression, schizophrenia, cardiovascular disorders, cancer, obesity, metabolic syndrome related diseases, Parkinson’s disease, Huntington’s disease, Alzheimer’s disease and Tourette’s syndrome could possibly be treated by drugs modulating the endocannabinoid system. 

Cannabinoid Receptors: What They Are and What They Do:

CB2 receptors are predominantly distributed in the immune system. They appear to be responsible for anti-inflammatory and other immune-related activity.

The two primary endocannabinoids produced by the human body interact directly with these receptors. . 

Many plants, not just Cannabis, contain phytocannabinoids – plant-based substances with an affinity for the cannabinoid receptors.

Cannabinoid Receptors You Probably Haven’t Heard About:

There is new evidence that suggests that the endocannabinoid system is more complex than first believed. Since 1999, we have learned that cannabinoids were still able to affect blood pressure, pain, inflammation, and gastric motility in the absence of CB1 and CB2 receptors.

This led to the discovery of at least eight other receptors to which cannabinoids bind. GPR18, GPR55, GPR119 have functions in the immune system, CNS, and gastrointestinal systems respectively, while others are capable of regulating pain transmission and cellular function.

Endocannabinoids bind to cannabinoid receptors on target cells throughout the body, triggering a cellular response which is amplified or diminished as metabolic enzymes destroy or make more endocannabinoids.

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Introductory offer:

‘Ultra High Potency’ 5 ml Sampler BCP+ 30x Liquid Extract Cannabinoid Oil @ $25. *plus $7. p & p OR $12. Rural delivery.

‘Ultra High Potency’ 20 ml BCP+ 30x Liquid Extract Cannabinoid Oil @ $99. *plus $7. p & p OR $12. Rural delivery.

*20 ml Special – Get an extra 5 ml Free! ( 25 ml ) Save $25. Sold Out!

‘Ultra High Potency’ 100 ml BCP+ 30x Liquid Extract Cannabinoid Oil @ $349. *plus p & p. *FREE POST. Save $

Available as an Olive Oil based BCP+ Cannabinoid Oil liquid Extract ( Olive Oil taste )

OR a VG – Vegetable Glycerine based BCP+ Cannabinoid Oil liquid Extract. ( *tastes sweet like honey with a hint of Liquorice )

‘Ultra High Potency’ 50 ml BCP+ 30x Extract Cannabinoid Balm @ $42. *plus p & p.

CONTACT:

nzonlineapothecary@gmail.com

nzonlineapothecary@gmail.com

*Payment via Online Banking. Trade Quantity, Bulk Purchase, NOT Supplied.

A case for the existence of a condition referred to as Clinical Endocannabinoid Deficiency?

Researchers believe that the underlying cause of many ailments, particularly those related to the immune system and inflammation, could be a disorder referred to as clinical endocannabinoid deficiency.

Endocannabinoid deficiency is a theory for the symptoms and conditions that develop when the body’s endocannabinoid system isn’t functioning properly. We’ve previously discussed the endocannabinoid system and its role in regulating a wide array of body processes to maintain our health.

The body naturally produces neuromodulatory lipids called endocannabinoids, which interact with cannabinoid receptors throughout the body to elicit chemical responses that keep the body in balance.

The theory of clinical endocannabinoid deficiency suggests that in some cases the body doesn’t produce enough endocannabinoids or enough receptors for the endocannabinoid system to function properly.

As a result, the many functions aren’t regulated properly and the body becomes unbalanced, allowing diseases to arise.

Renowned cannabinoid researcher Dr. Ethan Russo first proposed the theory of clinical endocannabinoid deficiency in 2004. In a study, published in Neuro Endocrinology Letters, Russo suggested that deficient cannabinoid levels might explain why some conditions develop.

Russo had examined the available literature and found evidence that people diagnosed with certain conditions had lower levels of endocannabinoids. He suggested that a person being deficient in endocannabinoids and/or cannabinoid receptors could explain why supplementing with cannabinoids found naturally present in some plants, (phytocannabinoids) were proving effective at alleviating some conditions.

“Migraine, fibromyalgia, [irritable bowel syndrome] and related conditions display common clinical, biochemical and pathophysiological patterns that suggests an underlying clinical endocannabinoid deficiency that may be suitably treated with cannabinoid medicines,” Russo concluded in his research review.

Cannabinoids found in plants (phytocannabinoids) are analogous to the endocannabinoids naturally produced by the body. Research shows that they interact with the cannabinoid receptors of the endocannabinoid system to elicit chemical responses that help bring about homeostasis. (equilibrium – balance)

A deficiency in endocannabinoids has been linked to several other disorders besides migraine, fibromyalgia and irritable bowel syndrome.

The endocannabinoid system is responsible for regulating the release of neurotransmitter, so diseases that are attributed to their dysfunction, such as Alzheimer’s disease and Parkinson’s disease, may be related to clinical endocannabinoid deficiency.

While more research needs to be done before endocannabinoid deficiency can be proven, the theory could open the door for methods to prevent and manage certain conditions.

Russo believes cannabinoids sourced naturally from plants, (phytocannabinoids) are essential nutrients that can minimize certain diseases by assisting the endocannabinoid system and ensuring that it functions properly.

Buy Online BCP+ Cannabinoid Oil beta Caryophyllene (BCP) – New Zealand N.Z

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